Each year, millions of hospital patients require treatment for fluid overload. This fluid overload leads to fatigue, edema, and shortness of breath and poor patient outcomes. Fluid overload can result from renal, liver or heart failure among other things, but heart failure is the most common underlying cause of fluid overload.
Currently, the vast majority of hospitalized fluid overload patients are treated with IV diuretics, inotropes and combination therapies. These pharmacological approaches may not always provide timely relief of symptoms without adverse effects. Patients manifest signs of persistent fluid overload for an average of 15 hours after admission1 and readmission rates are 30-60% within 6 months of initial discharge.2,3
There is another treatment alternative for fluid overload: isolated ultrafiltration, which uses an extracorporeal filter to remove isotonic fluid. Advantages may include:
- Therapy is controlled and predictable, removing fluid at commanded rates even when urinary output or diuretic responsiveness is low.
- Allows significant sodium removal while helping to avoid other electrolyte disturbances.
- A number of potential clinical advantages have been ascribed to ultrafiltration.
Despite these benefits, isolated ultrafiltration is currently used in only a small number of cases in the hospital. One limitation to increased utilization of ultrafiltration for fluid overload has been that traditional equipment is too complicated for such a simple therapy.
The NxStage System One overcomes this limitation, providing a simple platform to administer ultrafiltration therapy as part of an overall inpatient program.
- Cuffe, M. S., Califf, R. M., Adams, K. F. Jr, Benza, R., Bourge, R., Colucci, W. S., Massie, B. O'Connor, C. M., Pina, I., Quigg, R., Silver, M. A., & Gheorghiade, M. (2002). Journal of American Medical Association, 287, 1541-7.
- Jain, P., Massie, B. M., Gattis, W. A., Klein, L., & Gheorghiade, M. (2003). American Heart Journal, 145, S3-17.
- Klein, L., O'Connor, C. M., Gattis, W. A., Zampino, M., de Luca, L., Vitarelli, A., Fedele, F., & Gheorghiade, M. (2003). American Journal of Cardiology, 91, 18F-40F.