Home Hemodialysis Growth & Patient Demographics

Prior to FDA clearance of the NxStage System One, home hemodialysis (HHD) in the United States had experienced significant decline. According to the 2011 United States Renal Data System's Annual Data Report, which reflects data through 2009, the number of patients performing home hemodialysis treatments in the US had dropped from approximately 3,000 patients in 1990 to 1,761 patients in 2002. The NxStage System One has helped ignite a new wave of HHD therapy adoption, more than doubling the number of patients performing hemodialysis in their homes in its first 5 years on the market.

NxStage's home hemodialysis experience to date with the System One includes:

  • More than 4.5 million home hemodialysis treatments delivered
  • More than 5000 patients currently using the NxStage System One for home hemodialysis therapy.
  • Patients from the initial NxStage IDE study now active on therapy for more than 8 years

HHD in the U.S. back on the rise

Based on 2011 USRDS Annual Data Report (containing data through 2009) and NxStage data on file as of February 2011. USRDS patient data for 2010 not yet available. USRDS data from 2009 is carried forward to 2010 in this chart.

Who is doing home hemodialysis with NxStage?

Data on NxStage patient demographics is limited to that which is reported on individual patient prescriptions during therapy initiation or during a prescription change.

NxStage Patient Characteristics
  • 64% are male
  • Average age: 53 1/2 yrs
  • Average weight: 88kg
  • Vascular Access: 70% AV fistula
  • >90% patients doing 5-6 treatments per week

NxStage Data on File as of June 2011

Gender

NxStage home hemodialysis patients are more likely to be male.

NxStage data on file as of June 2011

2011 USRDS Annual Data Report

Age

With respect to age, there are a wide range of patients performing hemodialysis treatments at home with the NxStage System One.

NxStage data on file as of June 2011
NxStage does not have a specific pediatric indication.

2011 USRDS Annual Data Report

Weight

Approximately 60% of patients performing home hemodialysis treatments with the NxStage System One weigh over 80 kilograms (kgs), and nearly 30% weigh over 100kgs.

NxStage data on file as of June 2011

Therapy volume

The majority of patients are prescribed per session dialysate volumes in the range of 20 to 30 liters. More than 90% of patients performing HHD with the NxStage System One are performing treatments either 5 or 6 days per week.

NxStage data on file as of June 2011.

Vascular access

Most patients using the NxStage System One are using an AV fistula at therapy initiation, though many patients do use either a catheter or a graft as their primary access.

Data limited to patients for whom access type is reported at initiation of therapy

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