Research has shown that up to 30 percent of patients with kidney disease suffer from clinical depression. Low energy, lack of appetite, lack of interest in social activities, and changes in sleep habits are, unfortunately, common amongst dialysis patients. Moreover, studies have shown that an increase in depressive symptoms is associated with more frequent hospitalizations and even death. A major study of more than 9,000 patients with kidney failure has shown a clear association between depressive symptoms and patient death.
Here's what the FREEDOM study has shown:
One of the measures of NxStage's FREEDOM study is dialysis patients' depressive symptoms. FREEDOM study results found that patients who switched to daily home hemodialysis from in-center dialysis had significantly fewer symptoms of depression.
Despite the health benefits that more frequent home hemodialysis may provide to those with chronic kidney disease, this form of therapy is not for everyone. The reported benefits of more frequent home hemodialysis may not be experienced by all patients. The risks associated with hemodialysis treatments in any environment include, but are not limited to, high blood pressure, fluid overload, low blood pressure, heart-related issues, and vascular access complications. The medical devices used in hemodialysis therapies may add additional risks including air entering the bloodstream, and blood loss due to clotting or accidental disconnection of the blood tubing set. Certain risks are unique to the home. Treatments at home are done without the presence of medical personnel and on-site technical support. Patients and their care partners must be trained on what to do and how to get medical or technical help if needed.
To learn more about the responsibilities and risks of more frequent home hemodialysis, please click on Responsibilities & Risks of More Frequent Home Hemodialysis, and talk to your doctor to see if more frequent home hemodialysis with NxStage is right for you.
- Finkelstein F, et al. Daily home HD (DHD) improves quality of life (QOL) measures, depressive symptoms and recovery time: Interim results from the FREEDOM study. Abstract presentation at the American Society of Nephrology 2008 Annual Congress.
- Finkelstein F, et al. Daily hemodialysis improves depressive symptoms at 12 months of follow-up: Interim results from the FREEDOM study. Hemodialysis International. 2009;13(1):111.
- Finkelstein F, et al. Depression and end-stage renal disease: a therapeutic challenge. Kidney International. 2008;74:843-845.
- Lopes AA, et al. Screening for depression in hemodialysis patients: associations with diagnosis, treatment, and outcomes in the DOPPS. Kidney International. 2004;66: 2047-2053.
- Kimmel PL, et al. Multiple measurements of depression predict mortality in a longitudinal study of chronic hemodialysis outpatients. Kidney International. 2000;57:2093-2098.
- Lopes AA, et al. Depression as a predictor of mortality and hospitalization among hemodialysis patients in the United States and Europe. Kidney International. 2002;62:199-207.