First NxStage Home Hemodialysis Patients Celebrate Five-Year Anniversary

Tuesday January 6, 2009

LAWRENCE, Mass., Jan. 6 /PRNewswire-FirstCall/ — NxStage Medical, Inc. (Nasdaq: NXTM), a leading manufacturer of innovative dialysis products, today announced that a group of its first patients are celebrating their five-year anniversary of home hemodialysis treatment with the NxStage&reg System One&#153, the first truly portable home hemodialysis machine. Each of the four patients touts an improved quality of life characterized by better health and well being.

As early adopters of daily home hemodialysis with the NxStage System One, each of the patients arrived at the decision to try NxStage at various stages in their treatment. All four patients are followed by Satellite WellBound Centers, a NxStage partner that established the first program in NxStage’s IDE clinical study in 2003. These patients–Craig, Everett, Carl and Susan–began training with the NxStage System One on December 8th of 2003.

Carl emphasizes the significant health benefits of home hemodialysis

For Carl, who was diagnosed with kidney failure in 1996, in-center dialysis had been a physically grueling as well as intensely time-consuming process. After starting on NxStage, I felt like a new person compared to when I was doing in-center hemo, stated Carl. Five years later, Carl is still feeling well and enjoying the benefits of daily home hemodialysis with the NxStage System One.

Everett knew there had to be a better way

Following two failed kidney transplants, Everett relied upon in-center dialysis treatments that lasted anywhere from two to three and a half hours. Then he learned about a new treatment based on a portable hemodialysis machine. Five years later, Everett does his hemodialysis at home six times a week. I work treatments into my life, not the other way around, he insists. He’s gone back to playing basketball, a sport he always loved but hadn’t played in years due to fatigue.

Craig has taken his dialysis on the road

Craig has been dialysis-dependent since he was 19. When he heard about a new portable dialysis therapy that would enable him to do his treatments at home on a more frequent basis, Craig immediately knew the treatment option was for him. I bugged my doctor for a year, incessantly, until it was available, he says. In December 2003, he started training on NxStage. With the NxStage System One, Craig has been able to return to work part-time, exercise more often and pursue his passion of camping and traveling.

Susan felt NxStage gave me my life back

When Susan’s kidneys failed, she was forced to quit her job and go on permanent disability. Moreover, the fatigue and pain that ensued from her in-center dialysis treatments were completely incapacitating. After only one treatment on the NxStage System One, she recognized a difference in the way she felt. Just short of four years into her treatment with NxStage, Susan received a kidney transplant. Susan credits NxStage with helping her body feel healthy enough to sustain a transplanted kidney.

Our research and experience have shown that more frequent dialysis provides patients with improved health outcomes such as reduced hospitalizations and improved mortality rates, stated John Moran, MB, BS, FRACP, FASN, senior vice president of clinical affairs for Satellite Healthcare and WellBound. Daily home dialysis with NxStage is a tremendous treatment option for patients, and one from which many more dialysis patients could benefit.

NxStage’s founding mission is to give patients access to a range of dialysis therapies via the System One that deliver health benefits and meaningfully improve their quality of life, stated Jeffrey H. Burbank, founder and CEO of NxStage Medical, Inc. We look forward to expanding on the success of these patients to increase awareness and improve the quality of life for thousands of dialysis patients with our products.

About NxStage Medical

NxStage Medical, Inc. (Nasdaq: NXTM) is a medical device company, headquartered in Lawrence, Massachusetts, USA, that develops, manufactures and markets innovative products for the treatment of end-stage renal disease, or ESRD, and acute kidney failure. For more information on NxStage and its products, please visit the company’s website at http://www.nxstage.com.

The patient testimonials included in this release are examples of patient experiences on daily home hemodialysis with the NxStage System One. All patient experiences will vary, and there can be no assurance that all patients will experience these benefits. All hemodialysis involves some risk, and patients are encouraged to speak with their physicians to see if home dialysis with the NxStage System One is right for them.

Forward-Looking Statements

This release contains forward-looking statements within the meaning of the Private Securities Litigation Reform Act of 1995. All statements contained in this release that are not clearly historical in nature are forward-looking, and the words anticipate, believe, expect, estimate, plan, and similar expressions are generally intended to identify forward-looking statements. Actual results may differ materially from those indicated by these forward-looking statements as a result of various important factors including, but not limited to: market acceptance of the NxStage System One, the anticipated impact and results of daily hemodialysis, and other factors that are discussed in NxStage’s filings with the Securities and Exchange Commission, including the Quarterly Report on Form 10-Q for the quarter ended September 30, 2008. NxStage is under no obligation to (and expressly disclaims any such obligation to) update or alter its forward-looking statements, whether as a result of new information, future events or otherwise.

Contact:
Kristen K. Sheppard, Esq
VP, Investor Relations
ksheppard@nxstage.com

Jane Hauser
Schwartz Communications
nxstage@schwartz-pr.com
781-684-0770

SOURCE NxStage Medical, Inc.

Web Site: http://www.nxstage.com