Simplicity is critical.

7 of the top 10 renal care hospitals are now using the NxStage System One™

NxStage Critical Care

Critical care nurses rarely stand still. Neither does NxStage. That's why we're moving Continuous Renal Replacement Therapy (CRRT) nursing into the future with the System One.

Now in use at 7 of the 10 leading renal care hospitals (as ranked by U.S. News & World Report), its flexibility and simplicity continue to attract the attention of leading healthcare providers. The System One is designed to offer therapeutic and practical advantages as well multiple therapy options from a single efficient, portable machine.

Choose from wide flow rate ranges that allow continuous, extended, daily, or intermittent treatments that correspond to nursing shifts. Choose hemodialysis, hemofiltration, or isolated ultrafiltration all in one cartridge. A simplified OneView display provides real time treatment information as well as easy troubleshooting capabilities.

More nursing, less maintenance. It's the next stage of CRRT.

There are no effluent collection needs. No blood/air interface in the disposable cartridge (designed to optimize blood flow and reduce risk of clotting). Even scale maintenance is simplified thanks to innovative volumetric balancing chambers incorporated into a disposable cartridge.

It's inspiring, smart technology that lets caregivers give patients – not machines – their care. Reducing therapy complexity is essential – especially in light of staff workloads – to address today's clinical situation.

Our innovative approach is not just timely, it's supported.

Randomized clinical trial data supports the need for more intensive CRRT for acute renal failure (ARF) patients:

  • In a 160-patient study of more frequent vs. intermittent hemodialysis, mortality was reduced by 40% in the more frequent therapy arm.1
  • In a 425-patient study of CRRT patients, mortality was reduced by 30% when the volume of therapy delivered daily was increased by 75%.2
  • In addition, a 40-patient study showed extended daily therapies to have many of the stability benefits of CRRT in a simpler mode of administration.3

An invention inspired by reality.

More therapy generally means more work – labor, fluid handling, charting – for ICU nurses, which is simply not practical in today's environment. The nursing shortage is at a crisis level and is impacting patient outcomes4,5. Currently available equipment – conventional hemodialysis and dedicated critical care – both present challenges as therapy frequency and volume are increased.

Simply put, healthcare providers need solutions for acute renal care and fluid overload therapies that improve quality of care while reducing staff workload.

The NxStage System One is designed from the ground up to make intensive, CRRT therapies surprisingly simple.

  1. Schiffl, H., Lang, S.M., Fischer, R. (2002). Daily hemodialysis and the outcome of acute renal failure. The New England Journal of Medicine, 346, 305-310.
  2. Ronco, C., Bellomo, R., Homel, P., Brendolan, A., Dan, Maurizio., Piccinni, P., La Greca, G. (2000). Effects of different doses in continuous veno-venous haemofiltration on outcomes of acute renal failure: a prospective randomised trial. The Lancet, 356, 26-30.
  3. Kielstein, J., Kretschmer, U., Ernst, T., Hafer, C., Bahr, M., Haller, H., Fliser, D. (2004). Efficacy and cardiovascular tolerability of extended dialysis in critically ill patients: a randomized controlled study. American Journal of Kidney Diseases, 43, 342-349.
  4. Needleman, J., Buerhaus, P., Mattke, S., Steward, M., Zelevinsky, K. (2002). Nurse-staffing levels and the quality of care in hospitals. The New England Journal of Medicine, 346, 1715-1722.
  5. Aiken, L., Clarke, S., Sloane, D., Sochalski, J., Silber, J. (2002). Hospital nurse staffing and patient mortality, nurse burnout, and job dissatisfaction. Journal of the American Medical Association, 288, 1987-1993.
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