Home nocturnal hemodialysis is designed as a simple and practical extended therapy option for patients.
Duration matters, even with more frequent therapy
- Performing more frequent nocturnal hemodialysis has shown similar 5-year survivability rates as deceased donor transplantation.1
Better cardiovascular outcomes
- Regional Wall Motion Abnormalities (RWMAs) are associated with cardiac stunning and elevated mortality risk. Patients performing more frequent hemodialysis with lower Ultrafiltration (UF) rates resulted in a mean reduction of RWMAs as compared to conventional, thrice-weekly therapy with higher UF rates.2
Improved phosphorus control and middle molecule clearance
- Compared to conventional thrice-weekly in-center hemodialysis, nocturnal hemodialysis is associated with improved control of hyperphosphatemia, in addition to significantly higher total cleared volume both in Phosphorus and β2 microglobulin.3,4
Improved energy and vitality
- More frequent dialysis, during the day or overnight, may provide significant and wide-reaching therapeutic benefits.
- Quicker time to recovery5,6
- Less dietary restriction7
- Better blood pressure control with fewer medications8,9
- Pauly RP, Gill JS, Rose CL, et al. Survival among nocturnal home haemodialysis patients compared to kidney transplant recipients. Nephrol Dial Transplant. 2009;24:2915-2919.
- Jefferies et.al. Frequent hemodialysis schedules are associated with reduced levels of dialysis-induced cardiac injury (Myocardial stunning). Clin J Am Soc Neprhol. 2011;6(6):1326-1332.
- Raj DS, Ouwendyk M, Francoeur R, Pierratos A. ß2-Microglobulin kinetics in nocturnal haemodialysis. Nephrol Dial Transplant. 2000;15(1):58-64.
- Daugirdas JT, Chertow GM, Larive B, et al. Effects of frequent hemodialysis on measures of CKD mineral and bone disorder. J Am Soc Nephrol. 2012;23:727-738.
- Jaber BL, Lee Y, Collins AJ, et al. Effect of daily hemodialysis on depressive symptoms and postdialysis recovery time: interim report from the FREEDOM (Following Rehabilitation, Economics and Everyday-Dialysis Outcome Measurements) Study. Am J Kidney Dis. 2010;56(3):531-539.
- Lindsay RM, Heidenheim PA, Nesrallah G, Garg AX, Suri R, Daily Hemodialysis Study Group London Health Sciences Centre. Minutes to recovery after a hemodialysis session: a simple health-related quality of life question that is reliable, valid, and sensitive to change. Clin J Am Soc Nephrol. 2006;1(5):952-959.
- Spanner E, Suri R, Heidenheim AP, Lindsay RM. The impact of quotidian hemodialysis on nutrition. Am J Kidney Dis. 2003;42(1 suppl):30-35.
- Jaber BL, Collins AJ, Finkelstein FO, et al. Daily hemodialysis (DHD) reduces the need for antihypertensive medications. Abstract presented at American Society of Nephrology Conference, October 29, 2009.
- Kotanko P, Garg AX, Depner T, et al. Effects of frequent hemodialysis on blood pressure: Results from the randomized frequent hemodialysis network trials. Hemo Int. 2015;19(3):386-401.