First NxStage(R) Home Hemodialysis Patients Celebrate Seven-Year Anniversary

LAWRENCE, Mass., Dec. 16, 2010 /PRNewswire via COMTEX/ —

NxStage Medical, Inc. (Nasdaq: NXTM), a leading manufacturer of innovative dialysis products, today announced that a group of its first patients are celebrating their seven-year anniversary of home hemodialysis treatment with the NxStage^&reg System One^&#153, the only hemodialysis machine cleared by the FDA for home use. Each of these patients continues to experience the improved health and quality of life benefits possible with more frequent home hemodialysis using the System One.

As early adopters of daily home hemodialysis with the NxStage System One, each of the patients arrived at the decision to try NxStage at various stages in his treatment for end stage renal disease (ESRD). These patients–Craig, Carl, and Everette–began treatment with the NxStage System One in December, 2003 as part of NxStage’s groundbreaking clinical trial for its home indication.

Everettehad been undergoing in-center dialysis treatments when he learned about daily home hemodialysis with NxStage. For the past seven years, the NxStage System One has given me the freedom to live my life closer to the way I want to live it and allowed me to dedicate more time to my hobbies and business dreams, he said. Thanks in part to NxStage and dialyzing more frequently, I feel more healthy and active. I’ve come off several blood pressure medications and play basketball twice a week while spearheading my online clothing store.

This is a tremendous milestone not only for these patients, but also for all of our patients, prescribing nephrologists, partners and employees, stated Jeffrey H. Burbank, founder and CEO of NxStage Medical, Inc. We are extremely gratified to see these patients thriving and are excited to expand access to the life changing benefits possible with more frequent home hemodialysis using the System One to a growing number of patients worldwide.

You can read more about these patients and others on the NxStage website at https://www.nxstage.com/our_community/chronic_community/patients/patient_stories.cfm.

About NxStage Medical, Inc.

NxStage Medical, Inc. (Nasdaq: NXTM) is a medical device company, headquartered in Lawrence, Massachusetts, USA, that develops, manufactures and markets innovative products for the treatment of End Stage Renal Disease (ESRD) and acute kidney failure. For more information on NxStage and its products, please visit NxStage’s website at www.nxstage.com.

The patient testimonials included in this release are examples of patient experiences on home daily hemodialysis with the NxStage System One. All patient experiences will vary, and there can be no assurance that all patients will experience these benefits. All hemodialysis involves some risk, and patients are encouraged to speak with their physicians to see if home dialysis with the NxStage System One is right for them.

Forward-Looking Statements

This release contains forward-looking statements within the meaning of the Private Securities Litigation Reform Act of 1995. All statements contained in this release that are not clearly historical in nature are forward-looking, and the words anticipate, believe, expect, estimate, plan, and similar expressions are generally intended to identify forward-looking statements. Actual results may differ materially from those indicated by these forward-looking statements as a result of various important factors that are discussed in NxStage’s Quarterly Report on Form 10-Q for the period ended September 30, 2010 filed with the SEC. NxStage is under no obligation to (and expressly disclaims any such obligation to) update or alter its forward-looking statements, whether as a result of new information, future events or otherwise.

SOURCE NxStage Medical, Inc.