NxStage(R) Strengthens Medisystems(R) US Distributor Base with Metro Medical Supply, Inc.

Tuesday November 30, 2010

LAWRENCE, Mass., Nov. 30, 2010 /PRNewswire via COMTEX/ — NxStage Medical, Inc. (Nasdaq: NXTM), a leading manufacturer of innovative dialysis products, today announced that its Medisystems division has started distributing its in-center products through Metro Medical Supply, Inc., a leading full-service dialysis supplies provider. NxStage has given Metro Medical non-exclusive distribution rights to Medisystems’ products, including its premier bloodline, Streamline&reg and its MasterGuard&reg and ButtonHole&reg needles, to dialysis centers throughout the United States.

The combination of Medisystems’ high-quality, well-respected products and our industry leading customer base and extensive distribution network is a win for our customers, said Jim Brunner, Vice President of Metro Medical Supply, Inc. We’re pleased to align ourselves with a market leader.

We are delighted to be working with Metro Medical, said Mark Florence Vice President & General Manager, Medisystems. We believe Metro is well positioned to help expand and support customer access to our innovative, high value product lines, and we look forward to great successes together.

About Metro Medical Supply, Inc.

Metro Medical was founded in 1984 with the purpose of providing quality medical products to alternate site customers. The Company distributes a full line of pharmaceutical and medical- surgical supplies to physician practices, home care providers, long-term care facilities and dialysis centers throughout the United States.

About NxStage Medical, Inc.

NxStage Medical, Inc. (Nasdaq: NXTM) is a medical device company, headquartered in Lawrence, Massachusetts, USA, that develops, manufactures and markets innovative products for the treatment of End Stage Renal Disease (ESRD) and acute kidney failure. For more information on NxStage and its products, please visit NxStage’s website at http://www.nxstage.com/.

Forward-Looking Statements

This release contains forward-looking statements within the meaning of the Private Securities Litigation Reform Act of 1995. All statements contained in this release that are not clearly historical in nature are forward-looking, and the words anticipate, believe, expect, estimate, plan, and similar expressions are generally intended to identify forward-looking statements. Actual results may differ materially from those indicated by these forward-looking statements as a result of various important factors including Metro Medical Supply, Inc’s ability to expand and support customer access to Medisystems’ products, and factors that are discussed in NxStage’s Quarterly Report on Form 10-Q for the period ended September 30, 2010 filed with the SEC. NxStage is under no obligation to (and expressly disclaims any such obligation to) update or alter its forward-looking statements, whether as a result of new information, future events or otherwise.

NxStage Medical:

Kristen K. Sheppard, Esq.

VP, Investor Relations

ksheppard@nxstage.com

SOURCE NxStage Medical, Inc.