Home nocturnal hemodialysis is designed as a simple and practical extended therapy option for patients.

Duration matters, even with more frequent therapy

Improved survival

  • Performing more frequent nocturnal hemodialysis has shown similar 5-year survivability rates as deceased donor transplantation.1

Better cardiovascular outcomes

  • Regional Wall Motion Abnormalities (RWMAs) are associated with cardiac stunning and elevated mortality risk. Patients performing more frequent hemodialysis with lower Ultrafiltration (UF) rates resulted in a mean reduction of RWMAs as compared to conventional, thrice-weekly therapy with higher UF rates.2

Improved phosphorus control and middle molecule clearance

  • Compared to conventional thrice-weekly in-center hemodialysis, nocturnal hemodialysis is associated with improved control of hyperphosphatemia, in addition to significantly higher total cleared volume both in Phosphorus and β2 microglobulin.3,4

Improved energy and vitality

  • More frequent dialysis, during the day or overnight, may provide significant and wide-reaching therapeutic benefits.
    • Quicker time to recovery5,6
    • Less dietary restriction7
    • Better blood pressure control with fewer medications8,9
Risks and Responsibilities
  1. Pauly RP, Gill JS, Rose CL, et al. Survival among nocturnal home haemodialysis patients compared to kidney transplant recipients. Nephrol Dial Transplant. 2009;24:2915-2919.
  2. Jefferies et.al. Frequent hemodialysis schedules are associated with reduced levels of dialysis-induced cardiac injury (Myocardial stunning). Clin J Am Soc Neprhol. 2011;6(6):1326-1332.
  3. Raj DS, Ouwendyk M, Francoeur R, Pierratos A. ß2-Microglobulin kinetics in nocturnal haemodialysis. Nephrol Dial Transplant. 2000;15(1):58-64.
  4. Daugirdas JT, Chertow GM, Larive B, et al. Effects of frequent hemodialysis on measures of CKD mineral and bone disorder. J Am Soc Nephrol. 2012;23:727-738.
  5. Jaber BL, Lee Y, Collins AJ, et al. Effect of daily hemodialysis on depressive symptoms and postdialysis recovery time: interim report from the FREEDOM (Following Rehabilitation, Economics and Everyday-Dialysis Outcome Measurements) Study. Am J Kidney Dis. 2010;56(3):531-539.
  6. Lindsay RM, Heidenheim PA, Nesrallah G, Garg AX, Suri R, Daily Hemodialysis Study Group London Health Sciences Centre. Minutes to recovery after a hemodialysis session: a simple health-related quality of life question that is reliable, valid, and sensitive to change. Clin J Am Soc Nephrol. 2006;1(5):952-959.
  7. Spanner E, Suri R, Heidenheim AP, Lindsay RM. The impact of quotidian hemodialysis on nutrition. Am J Kidney Dis. 2003;42(1 suppl):30-35.
  8. Jaber BL, Collins AJ, Finkelstein FO, et al. Daily hemodialysis (DHD) reduces the need for antihypertensive medications. Abstract presented at American Society of Nephrology Conference, October 29, 2009.
  9. Kotanko P, Garg AX, Depner T, et al. Effects of frequent hemodialysis on blood pressure: Results from the randomized frequent hemodialysis network trials. Hemo Int. 2015;19(3):386-401.